Sensitivity of Mycobacterium leprae to Telacebec
نویسندگان
چکیده
Abstract The treatment of leprosy is long and complex, benefiting from the development sterilizing, rapidly-acting drugs. Reductive evolution made Mycobacterium leprae exquisitely sensitive to Telacebec, a phase 2 drug candidate for tuberculosis. unprecedented potency Telacebec against M. warrants further validation in clinical trials.
منابع مشابه
Structure of Mycobacterium leprae.
Introduction : why study structure? Information about the structure of M. leprae may be obtained by microscopy (especially electron miscroscopy) and other physical techniques . There is active development of such techniques , but at present the information they can give about structures as complex as a bac terium is l imited . To obtain a detailed knowledge of the molecular composition and con...
متن کاملCytokine responses to Mycobacterium leprae unique proteins differentiate between Mycobacterium leprae infected and naive armadillos.
New diagnostic tools for early detection of leprosy are necessary to help reduce its transmission and severity. M. leprae unique proteins have been used to assess differences in human T-cell responses in leprosy patients, household contacts and endemic controls. In this study, we examined the response of M. leprae-infected armadillos to a variety of M. leprae recombinant antigen candidates curr...
متن کاملCellular Reactions to Waxes from Mycobacterium Leprae
1. The waxes from the B. leprae, like those from tubercle bacilli, are remarkable stimulants of cells. 2. The crude wax separated from the B. leprae is a mixture of lipoids and other materials, and gives reactions that include the types of cells characteristic of the response to the tuberculo-polysaccharide, phosphatide, and wax. 3. The wax obtained from the purification of the lepra phosphatid...
متن کاملAdjuvant activity of Mycobacterium leprae.
Mycobacterium leprae organisms isolated from infected spleen and liver tissue by zonal centrifugation were shown to possess adjuvant activity. Histochemical examination of the footpad macrophage epithelioid granuloma showed that macrophages contained large amounts of hemosiderin after the injection of M. leprae and much smaller amounts after the injection of M. tuberculosis.
متن کاملMycobacterium leprae. A multifactorial approach
Evidence is accumulating that Mycobacterium leprae is probably a microbe dependent microbe. l O1 3 The first report that multiplication of M. leprae was promoted by a growth factor of mycobacterial origin was proposed by Twort l 9 in 1 9 1 0 , two years before the discovery of the cultivation of 'lohne's bacilli' in media enriched with heat-killed mycobacteria . 2o The growth factor was identi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Emerging Infectious Diseases
سال: 2022
ISSN: ['1080-6059', '1080-6040']
DOI: https://doi.org/10.3201/2803.210394